University of Maryland School of Medicine  
PKD Core Center
Antibody Validation/Vector Core Mouse Models BioBank Core
Cell Culture Cell Engineering Core Clinical Translational Core

•  Application Information

Current Projects

Katharina Hopp, Ph.D.
"Evaluating kynurenine pathway catabolites as biomarker for ADPKD progression and driver of a pro-cystogenic microenvironment"

Yong Yu, Ph.D.
"The molecular mechanism of the function of the polycystin-1/polycystin 2 ion channel complex"

Weibin Zhou, Ph.D.
"Screening for Genetic Modifiers of ADPKD Using Gynogenetic Haploid Zebrafish"

Projects Funded in Year 8:

Brian Adair, Ph.D.
"Structure and function of polycystin-1"

Keith Mostov, M.D.
"The Paradox of Intestinal Cell Kinase: Hyperproliferation in Renal Cysts, but Hypoproliferation in Short Small Intestine"

Sean Sun, Ph.D.
"Mechanics of growth and fluid secretion in the renal epithelium and early onset of PKD"

Projects Funded in Year 7:

Meyeon Park, M.D., M.A.S
"Novel Strategies for Cardiovascular Risk Reduction in Adults with PKD"

Tengis Pavlov, Ph.D.
"Role of P2X Signaling in the Development of PKD"

Shoshana Weiner, M.D., M.P.H.
"Use of an Interactive Text Messaging System to Promote Water Intake in Autosomal Dominant Polycystic Kidney Disease"

Projects Funded in Year 6:

Andrew Holland, M.A., Ph.D
"Genetic Modulation of Centriole Number and its Impact on Kidney Signaling and Function"

Daniel Judge, M.D.
"Cardiac Response to Gene Mutations Affecting the Primary Cilium"

Projects Funded in Year 5:

Kenneth Hallows, M.D., Ph.D.
"Effects of Metformin on the AMPK Pathway and Metabolic Biomarkers in ADPKD Kidney Epithelial Cells"

Owen Woodward, Ph.D.
"Mechanisms of Fluid Secretion and Cystic Expansion in New ADPKD Kidney Organoid 3D Model"

Kyung Lee, Ph.D.
“Inhibition of Intergrin β1 Protects Against the Development and Progression of ADPKD”

Funded Projects in Year 4:

Richard Bouley, Ph.D.
"Vasopressin Receptor Type 2 Intracellular Trafficking and Signaling in PKD"

Tianqing Kong, M.D.
"Ga12 Activation Disrupts Renal Epithelial Cell-Cell Integrity in ADPKD"

Leon McClean, MD, MPH
"Polycystins in Intestinal Mucosal Homeostatsis and Development of Murine Colitis"

Norann Zaghloul, Ph.D.
"Notch Signaling in Renal Ciliopathies"

Funded Projects in Year 3:

Andrew Ewald, Ph.D.
"Real-Time Analysis of PKD1 and PKD2 Dependent Cyst Formation"

Steven Kleene, Ph.D.
"Electrical Signaling of Wildtype and Mutated Human Polycystin-2 Channels in a Primary Cilium"

Funded Projects in Years 1 and 2:

Andrew Ewald, Ph.D.
“PKD1 and Mammary Branching Morphogenesis.”

Duojia Pan, Ph.D.
“Exploring the Role of Hippo Signaling in PKD Pathogenesis.”

Raquel Greer Charles, M.D.
"Perceived Risks and Willingness to Participate in Clinical Research of Autosomal Dominant Polycystic Kidney Disease among Ethnic/Racial Minorities."

Takanari Inoue, Ph.D.
“Quantitative Chemical Biology Approach for Characterization of Polycystin 1 and 2 in Renal Tubulogenesis.”

Subroto Chatterjee, Ph.D.
"Testing a Novel Glycolipid Inhibitor for Treatment of PKD using an Orthologous Mouse Model."

Eduational Programs Pilot & Feasibility Program

The University of Maryland Medical Center and the Division of Nephrology provide multidisciplinary care for patients with PKD. For Appointments call 410-328-5720 and ask for Karleen Schuhart. Make an appointment.

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