University of Maryland School of Medicine  
PKD Core Center
Antibody Validation/Vector Core Mouse Models BioBank Core
Cell Culture Cell Engineering Core Clinical Translational Core
Publications
Supported by the Baltimore PKD Center (From 2015)
  1. Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics. 47:24-32, 2015. PMID: 25492927
    Support: Pilot and Feasibility
  2. Lim Y, Gondek L, Li L, Wang Q, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W. Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med.;7(291):291ra96, 2015. PMID: 26062848 PMCID: PMC4644635
    Support: Core B
  3. Xu Q, Zhang Y, Wei Q, Huang Y, Li Y, Ling K, Hu J. BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors. Sci Rep. 5:11855, 2015. PMID: 26150102 PMCID: PMC4493597
    Support: Core B
  4. Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; for Conference Participants. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 88: 17-27, 2015. PMID: 25786098
    Support: Core E
  5. Woodward OM. ABCG2: the molecular mechanisms of urate secretion and gout. Am J Physiol Renal Physiol. 309: F485-8, 2015. PMID: 26136557
    Support: Pilot and Feasibility
  6. Hofherr A, Wagner CJ, Watnick T, Köttgen M. Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition. Kidney Int. 89:949-55, 2016. PMID: 26924047.
    Support: Core B
  7. Perrone RD, Malek AM, Watnick T. Vascular complications in autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 11: 589-98, 2015. PMID: 26260542
    Support: Core E
  8. Qian F. The Role of GPS cleavage in Polycystin-1 Biogenesis, Trafficking and Function, in "Polycystic Kidney Disease". Codon Publications, Australia. October 2015.
    Support: Core B
  9. Trudel M, Yao Q, Qian F. The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease. Cells. 2016 Jan 21;5(1). pii: E3. doi:10.3390/cells5010003. PMID: 26805887
    Support: Core B
  10. Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, and Boletta A. mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex. Nat Commun. 7:10786, 2016. PMID: 26931735.
    Support: Core B
  11. Cebotaru L, Liu Q, Yanda M, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V. Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. Kidney Int. 90:90- 9, 2016. PMID: 27165822
    Support: Core B, C, D
  12. Cebotaru L, Cebotaru V, Wang H, Arend LJ, Guggino WB. STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance. Cell Physiol Biochem. 39:172-82, 2016. PMID: 27336410 PMID: 27336410
    Support: Core C
  13. Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai C-X, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L. The polycystin complex mediates WNT/Ca2+ signaling. Nat Cell Biol. 18:752-64, 2016. PMID: 27214281
    Support: Core B, C, D
  14. Ta M, Schwensen K, Liuwantara D, Huso DL, Watnick T, Rangan GK. Constitutive renal Rel/NF-kB expression in Lewis polycystic kidney disease rats. World J Nephrol. :339-57, 2016. PMID: 27458563
    Support: Core C
  15. McLean LP, Smith A, Cheung L, Sun R, Grinchuk V, Vanuytsel T, Desai N, Urban JF Jr, Zhao A, Raufman JP, Shea-Donohue T. Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium. Inflamm Bowel Dis. 21:1860-71, 2015. PMID: 25985244
    Support: Pilot and Feasibility
  16. McLean LP, Cross RK. Integrin Antagonists as Potential Therapeutic Options for the Treatment of Crohn’s Disease. Expert Opinion Invest Drugs. 25:263-73, 2016. PMID: 26822204
    Support: Pilot and Feasibility
  17. McLean LP, Cross RK. Pharmacodynamic assessment of vedolizumab for the treatment of ulcerative colitis. Expert Opin Drug Metab Toxicol. 2016 Apr 20. PMID: 27096357
    Support: Pilot and Feasibility
  18. McLean LP, Smith A, Cheung L, Sun R, Grinchuk V, Desai N, Urban JF, Zhao A, Raufman JP, SheaDonohue T. Type 3 Muscarinic Receptors Contribute to Clearance of Nippostrongylus brasiliensis through Induction of Th2 Cytokines. Am J Physiol Gastrointest Liver Physiol. 311: G130-41, 2016. PMID: 27173511
    Support: Pilot and Feasibility
  19. "EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Jenny Lu HA, Brown D, Bouley R. J Am Soc Nephrol. 27:3105-3116, 2016. PMID: 27694161 PMCID: PMC5042667 Selected as an F1000 prime article
    Support: Pilot and Feasibility
  20. Hostelley, T.L., Lodh, S., Zaghloul, N.A. (2016) “Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alstrom Syndrome provides mechanistic insight into shared and divergent phenotypes.” BMC Genomics 17:318, 2016. PMID: 27142762
    Support: Pilot and Feasibility
  21. Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ, Köttgen M. Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch. 469:303-311, 2017. PMID: 27987038
    Support: Core B
  22. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell167:763-773, 2016. PMID: 27768895,
    Support: Core B
  23. Kleene SJ and Kleene NK. The native TRPP2-dependent channel of murine renal primary cilia. Am J Physiol Renal Physiol. 312: F96-F108, 2017. PMID: 27760766
    Support: Pilot and Feasibility
  24. Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DP. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One. 2016 May 19;11(5): e0155577. doi: 10.1371/journal.pone.0155577. eCollection 2016. PMID: 27196058
    Support: Core C
  25. Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S. Isolated polycystic liver disease genes define effectors of polycystin-1 function. J Clin Invest 127: 1772-85, 2017. PMID: 28375157
    Support: Core E
  26. Porath B, Gainullin VG, Cornec-Le Gall E, Dillinger EK, Heyer CM, Hopp K, Edwards ME, Madsen CD, Mauritz SR, Banks CJ, Baheti S, Reddy B, Herrero JI, Bañales JM, Hogan MC, Tasic V, Watnick TJ, Chapman AB, Vigneau C, Lavainne F, Audrézet MP, Ferec C, Le Meur Y, Torres VE; Genkyst Study Group, HALT Progression of Polycystic Kidney Disease Group.; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease., Harris PC. Am J Hum Genet. 98:1193-207, 2016. PMID: 27259053
    Support: Core E
  27. Wu Y, Xu JX, El-Jouni W, Lu T, Li S, Wang Q, Tran M, Yu W, Wu M, Barrera IE, Bonventre JV, Zhou J, Denker BM, Kong T. Gα12 is required for renal cystogenesis induced by Pkd1 inactivation. J Cell Sci. 129:3675-3684, 2016. PMID: 27505895 PMCID: PMC5087651
    Support: Pilot and Feasibility
  28. Balbo BE, Amaral AG, Fonseca JM, de Castro I, Salemi VM, Souza LE, Dos Santos F, Irigoyen MC, Qian F, Chammas R, Onuchic LF. Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout. Kidney Int. 90: 580-97, 2016. PMID: 27475230
    Support: Core B, C
  29. Dalagiorgou G, Piperi C, Adamopoulos C, Georgopoulou U, Gargalionis AN, Spyropoulou A, Zoi I, Nokhbehsaim M, Damanaki A, Deschner J, Basdra EK, Papavassiliou AG. Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis. Cell Mol Life Sci. 74:921-936, 2017. PMID: 27699453
    Support: Core B
  30. Liu Y, Pejchinovski M, Wang X, Fu X, Castelletti D, Watnick TJ, Arcaro A, Siwy J, Mullen W9, Mischak H, Serra AL. Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease. Sci Rep. 2018 Apr 3; 8(1):5584. doi: 10.1038/s41598-018-22938. PMID: 29615724
    Support: Core C
  31. Gulati A, Bae KT, Somlo S, Watnick T. Genomic Analysis to Avoid Misdiagnosis of Adults with Bilateral Renal Cysts. Ann Intern Med. :130-131, 2018. PMID: 29582070
    Support: Core E
  32. Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu L-K, Lee P-H, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG. A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci Rep. 2018 Feb 9;8(1):2743. doi: 10.1038/s41598-018-20856-6. PMID: 29426897 PMCID: PMC5807443
    Support: Core C
  33. Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology. Sci Rep. 2017 Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4. PMID: 28798345 PMCID: PMC5552802
    Support: Core C
  34. Outeda P, Menezes L, Hartung EA, Bridges S, Zhou F, Zhu X, Xu H, Huang Q, Yao Q, Qian F, Germino GG, Watnick T. A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin Cterminus in disease mechanism. Kidney Int 92:1130-1144, 2017. PMID: 28729032
    Support: Core B, C
  35. Seliger S, Abebe K, Hallows K, Miskulin D, Perrone R, Watnick T, Bae K. A Randomized Clinical Trial of Metformin to treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 47:352-360, 2018. PMID: 29779024
    Support: Core E
  36. Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ. Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Dev Cell 40:313-322, 2017. PMID: 28132847 PMCID: PMC5296221
    Support: Pilot and Feasibility
  37. Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. J Biol Chem 292:17897- 17908, 2017. PMID: 28887310 PMCID: PMC5663887
    Support: Core C,D
  38. Rajani R1, Pastor-Soler NM, Hallows KR. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens 26: 375-383, 2017. PMID: 28614117
    Support: Pilot and Feasibility
  39. Yanda MK, Liu Q, Cebotaru L. An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease. Am J Physiol Renal Physiol 313: F997-F1004, 2017. PMID: 28747357 PMCID: PMC5668593
    Support: Core C
  40. Nie X, Arend LJ. Deletion of Pkd1 in renal stromal cells causes defects in the renal stromal compartment and progressive cystogenesis in the kidney. Lab Invest. 97(12):1427-1438, 2017. PMID: 28892094
    Support: Core C
  41. He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M. Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proc Natl Acad Sci U S A. 114(45):E9559-E9568, 2017. PMID: 29078380
    Support: Pilot and Feasibility
  42. Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ, Köttgen M. Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch 469:303-311, 2017. 1007/s00424-016-1924-4. PMID: 27987038 PMCID: PMC5222933
    Support: Core B
  43. Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schütze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T, Köttgen M. The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. PLoS Biol. 2018 Aug 6;16(8):e2005651. doi: 10.1371/journal.pbio.2005651. PMID: 30080851
    Support: Core B, D
  44. Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, Pan D. A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev. 32: 781-793, 2018. PMID: 29891559
    Support: Pilot and Feasibility, Core B, C
  45. Dixon EE, Woodward OM. Three-dimensional in vitro models answer the right questions in ADPKD cystogenesis. Am J Physiol Renal Physiol. 315:F332-F335, 2018. PMID: 29693448.
    Support: Pilot and Feasibility, Core D
  46. Parnell SC, Magenheimer BS, Maser RL, Pavlov TS, Havens MA, Hastings ML, Jackson SF, Ward CJ, Peterson KR Staruschenko A, Calvet JP. A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD. Hum Mol Genet. 27:3313-3324, 2018. PMID: 29931260. PMCID: PMC6140781
    Support: Core B
  47. Podrini C, Rowe I, Pagliarini R, Costa ASH, Di Meo I, Kim H, Chiaravalli M, Di Stefano G, Tiranti V, Qian F, di Bernardo D, Frezza C, Boletta A. Dissection of Metabolic Reprogramming in Polycystic Kidney Disease Reveals a Complex and Coordinated Rewiring of Bioenergetic Pathways. Commun Biol. 67:109495, 2018. PMID: 30480096
    Support Core B, C
  48. Welling PA. Autosomal dominant PKD gets an atomic map. Nat Rev Nephrol. 14:725-726, 2018. PMID: 30279534
    Support: Core D
  49. Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Role of calcium in adult onset polycystic kidney disease. Cell Signal. 53:140-150, 2018. PMID: 30296477
    Support: Core B, D
  50. Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation. 138:1623-1635, 2018. PMID: 30354459
    Support: Core E
  51. Yanda MK, Liu Q, Cebotaru L. A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector. J Biol Chem. 293:11513-11526, 2018. PMID: 29875161
    Support: Core C
  52. He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, Torline J, Huang Y, Zhao J, Ling K, Hu J. Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling. Nat Commun. 9:3310, 2018. PMID: 30120249 Free PMC Article
    Support: Core B
  53. Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates CR, Li W, Dong B, Waters CM, Smith JC, Quarles LD. Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 128:157-174, 2018. PMID: 29202470 Free PMC Article
    Support: Core C
  54. Kwak M, Hong C, Myeong J, Park EYJ, Jeon JH, So I. Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation. Sci Rep. 8:3480, 2018. PMID: 29472562 PMCID: PMC5823873
    Support: Core B
  55. Prasad H, Dang DK, Kondapalli KC, Natarajan N, Cebotaru V and Rao R. NHA2 promotes cyst development in an in vitro model of polycystic kidney disease. J Physiol. 597:499-519, 2019. PMID: 30242840
    Support: Core B
  56. Fitzgibbon WR, Dang Y, Bunni MA, Baicu CF, Zile MR, Mullick AE, Saigusa T. Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade. Am J Physiol Renal Physiol: 314: F210-F218, 2018. PMID: 29021226
    Support: Core C
  57. Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE. A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan. J Am Soc Nephrol. 29:2458-2470, 2018. PMID: 30228150
    Support: A, E
  58. Woodward O and Watnick T. Molecular Structure of the PKD Protein Complex Finally Solved. Am J Kidney Dis. 73: 620-623, 2019. PMID: 30704879
    Support: Core D, A
  59. Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Role of calcium in adult onset polycystic kidney disease. Cell Signaling 53:140-150, 2019. PMID: 30296477
    Support: Core C
  60. Kashyap P, Ng C, Wang Z, Li B, Arif Pavel M, Martin H, Yu Y. A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site. Biochem Biophys Res Commun. 512:812-818, 2019. PMID: 30928102
    Support: Pilot and Feasibility
  61. Chu H, Shillingford JM, Reddy JA, Westrick E1, Nelson M, Wang EZ, Parker N, Felten AE, Vaughn JF, Xu LC, Lu YJ, Vlahov IR, Leamon CP. Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys. Mol Pharm16: 3985-3995, 2019. PMID: 31356752
    Support: Core C
  62. Wang Z, Ng C, Liu X, Wang Y, Li B, Kashyap P, Chaudhry HA, Castro A, Kalontar EM, Ilyayev L, Walker R, Alexander RT, Qian F, Chen XZ2, Yu Y. The ion channel function of polycystin-1 in the polycystin1/polycystin-2 complex. EMBO Rep. 2019 Aug 22: e48336. doi: 10.15252/embr.201948336. [Epub ahead of print]
    Support: Core B
  63. Hwang SH, Somatilaka BN, Badgandi H, Palicharla VR, Walker R, Shelton JM, Qian F, Mukhopadhyay S. Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia. Curr Biol. 29:790-802, 2019. PMID: 30799239
    Support: Core B
  64. Lassen MCH, Qasim AN, Biering-Sørensen T, Reeh JLT, Watnick T, Seliger SL, Chen H, Sawan MA, Nguyen D, Li Y, Hong SN, Park M. Cardiac function assessed by myocardial deformation in adult polycystic kidney disease patients. BMC Nephrol. 20:324, 2019. PMID: 31419965
    Support: Core E, Pilot and Feasibility
  65. Palygin O, Ilatovskaya DV, Levchenko V, Klemens CA, Dissanayake L, Williams AM, Pavlov TS, Staruschenko A. Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal: 14:485-497, 2018. PMID: 30417216
    Support: Pilot and Feasibility
  66. Arkhipov SN, Pavlov TS. ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity. Biochem Biophys Res Commun. 513:166-171, 2019. PMID: 30417216
    Support: Pilot and Feasibility
  67. Ilatovskaya DV, Levchenko V, Pavlov TS, Isaeva E, Klemens CA, Johnson J, Liu P, Kriegel AJ, Staruschenko A. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). EBioMedicine 40:663-674, 2019. PMID: 30745171
    Support: Pilot and Feasibility
  68. Paul P, Ramachandran S, Xia S, Unruh JR, Conkright-Fincham J, Li R. Dopamine receptor antagonists as potential therapeutic agents for ADPKD. PLoS One. 2019 May 6;14(5):e0216220. doi:10.1371/journal.pone.0216220, 2019. PMID: 31059522
    Support: Core A
  69. Román-Fernández Á, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE, Bryant DM. The phospholipid PI(3,4)P2 is an apical identity determinant. Nat Commun. 2018 Nov 28;9(1):5041. doi: 10.1038/s41467-018-07464-8. PMID: 30487552
    Support: Pilot and Feasibility
  70. Hopp K, Cornec-Le Gall E, Senum SR, Te Paske IBAW, Raj S, Lavu S, Baheti S, Edwards ME, Madsen CD, Heyer CM, Ong ACM, Bae KT, Fatica R, Steinman TI, Chapman AB, Gitomer B, Perrone RD, RahbariOskoui FF, Torres VE; HALT Progression of Polycystic Kidney Disease Group, the ADPKD Modifier Study, Harris PC. Kidney Int. 97:370-382, 2020. PMID: 31874800
    Support: Core E, Pilot and Feasibility
  71. Chen H, Watnick T, Hong SN, Daly B, Li Y, Seliger SL. Left ventricular hypertrophy in a contemporary cohort of autosomal dominant polycystic kidney disease patients. BMC Nephrol. 20:386, 2019. PMID: 31653199
    Support: Core E
  72. Wang K, Zelnick LR, Chen Y, Hoofnagle AN, Watnick T, Seliger S, Kestenbaum B. Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol15:80-88, 2020.
    Support: Core E
  73. Nemenoff RA, Kleczko EK, Hopp K. Renal double negative T cells: unconventional cells in search of a function. Ann Transl Med. 7(Suppl 8): S342, 2019. PMID: 32016060 PMCID: PMC6976428
    Support: Pilot and Feasibility
  74. Nowak KL, Hopp K. Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential. In press Clin J Am Soc Nephrol. 2020 PMID: 32086281
    Support: Pilot and Feasibility
  75. Nowak KL and Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cellular Signaling, 68:109518. doi: 10.1016/j.cellsig.2019.109518, 2020
    PMID: 31881325
    Support: Pilot and Feasibility
  76. Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM, Norris DP.
    Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney
    disease model. Nat Commun. 2019 Sep 6;10(1):4072. doi: 10.1038/s41467-019-12067-y.
    PMID: 31492868
    Support: Core B
  77. Holditch SJ , Brown CN, Atwood DJ, Pokhrel D, Brown SE, Lombardi AM, Nguyen KN, Hill RC, Lanaspa M,
    Hopp K, Weiser-Evans MCM, Edelstein CL. The consequences of increased 4E-BP1 in polycystic kidney disease. Hum Mol Genet. 28: 4132-4147, 2019.
    Support: Core D, E
  78. Lea WA, McGreal K, Sharma M, Parnell SC, Zelenchuk L, Charlesworth MC, Madden BJ, Johnson KL, McCormick DJ, Hogan MC, Ward CJ. Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs). Sci Rep 10, 1500 (2020 doi: 10.1038/s41598-020-58087-3.
    PMID: 32001768
    Support: Core B
  79. Zimmerman KA, Huang J, He L, Revell DZ, Li Z, Hsu J-S, Fitzgibbon WR, Hazard ES, Hardiman G, Mrug M, Bell PD, Yoder BK, Saigusa T. Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney Disease. Kidney360 March 2020, 1 (3) 179-190; DOI: https://doi.org/10.34067/KID.0001052019 In Press, final not out yet
    Support: Pilot and Feasibility
  80. Walker R, Xu H, Huang Q and Qian F. Biochemical Analysis of the Polycystin-1 Complexity Generated
    by Proteolytic Cleavage at the G Protein-Coupled Receptor Proteolysis Site. In book: Polycystic Kidney Disease, pp.1-23. CRC Press eBook Published24 October 2019. DOI: 10.1201/9780429468834-1
    Support: Core B
  81. Outeda P and Watnick T. Methods to Study the Vasculature in ADPKD. In book: Polycystic Kidney Disease. Boca Raton: CRC Press, 2019. eBook. DOI: 10.1201/9780429468834.
    Support: Core C, A
Eduational Programs Pilot & Feasibility Program

The University of Maryland Medical Center and the Division of Nephrology provide multidisciplinary care for patients with PKD. For Appointments call 410-328-5720 and ask for Karleen Schuhart. Make an appointment.

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