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Publications Supported by the Baltimore PKD Center (From 2015)
- Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and Gα12 regulate the
cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics. 47:24-32, 2015.
PMID: 25492927
Support: Pilot and Feasibility
- Lim Y, Gondek L, Li L, Wang Q, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins
DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W. Integration of Hedgehog and mutant
FLT3 signaling in myeloid leukemia. Sci Transl Med.;7(291):291ra96, 2015.
PMID: 26062848 PMCID: PMC4644635
Support: Core B
- Xu Q, Zhang Y, Wei Q, Huang Y, Li Y, Ling K, Hu J. BBS4 and BBS5 show functional redundancy in the
BBSome to regulate the degradative sorting of ciliary sensory receptors. Sci Rep. 5:11855, 2015.
PMID: 26150102 PMCID: PMC4493597
Support: Core B
- Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y,
Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; for Conference Participants.
Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease:
Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 88: 17-27, 2015.
PMID: 25786098
Support: Core E
- Woodward OM. ABCG2: the molecular mechanisms of urate secretion and gout. Am J Physiol Renal
Physiol. 309: F485-8, 2015.
PMID: 26136557
Support: Pilot and Feasibility
- Hofherr A, Wagner CJ, Watnick T, Köttgen M. Targeted rescue of a polycystic kidney disease mutation by
lysosomal inhibition. Kidney Int. 89:949-55, 2016.
PMID: 26924047.
Support: Core B
- Perrone RD, Malek AM, Watnick T. Vascular complications in autosomal dominant polycystic kidney
disease. Nat Rev Nephrol. 11: 589-98, 2015.
PMID: 26260542
Support: Core E
- Qian F. The Role of GPS cleavage in Polycystin-1 Biogenesis, Trafficking and Function, in "Polycystic
Kidney Disease". Codon Publications, Australia. October 2015.
Support: Core B
- Trudel M, Yao Q, Qian F. The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1
in Renal Physiology and Polycystic Kidney Disease. Cells. 2016 Jan 21;5(1). pii: E3.
doi:10.3390/cells5010003.
PMID: 26805887
Support: Core B
- Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, and Boletta A.
mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis
complex. Nat Commun. 7:10786, 2016.
PMID: 26931735.
Support: Core B
- Cebotaru L, Liu Q, Yanda M, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V.
Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. Kidney Int. 90:90-
9, 2016. PMID: 27165822
Support: Core B, C, D
- Cebotaru L, Cebotaru V, Wang H, Arend LJ, Guggino WB. STIM1fl/fl Ksp-Cre Mouse has Impaired Renal
Water Balance. Cell Physiol Biochem. 39:172-82, 2016. PMID: 27336410
PMID: 27336410
Support: Core C
- Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai C-X, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L.
The polycystin complex mediates WNT/Ca2+ signaling. Nat Cell Biol. 18:752-64, 2016.
PMID: 27214281
Support: Core B, C, D
- Ta M, Schwensen K, Liuwantara D, Huso DL, Watnick T, Rangan GK. Constitutive renal Rel/NF-kB
expression in Lewis polycystic kidney disease rats. World J Nephrol. :339-57, 2016.
PMID: 27458563
Support: Core C
- McLean LP, Smith A, Cheung L, Sun R, Grinchuk V, Vanuytsel T, Desai N, Urban JF Jr, Zhao A, Raufman
JP, Shea-Donohue T. Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium. Inflamm
Bowel Dis. 21:1860-71, 2015.
PMID: 25985244
Support: Pilot and Feasibility
- McLean LP, Cross RK. Integrin Antagonists as Potential Therapeutic Options for the Treatment of Crohn’s
Disease. Expert Opinion Invest Drugs. 25:263-73, 2016.
PMID: 26822204
Support: Pilot and Feasibility
- McLean LP, Cross RK. Pharmacodynamic assessment of vedolizumab for the treatment of ulcerative
colitis. Expert Opin Drug Metab Toxicol. 2016 Apr 20.
PMID: 27096357
Support: Pilot and Feasibility
- McLean LP, Smith A, Cheung L, Sun R, Grinchuk V, Desai N, Urban JF, Zhao A, Raufman JP, SheaDonohue T. Type 3 Muscarinic Receptors Contribute to Clearance of Nippostrongylus brasiliensis through
Induction of Th2 Cytokines. Am J Physiol Gastrointest Liver Physiol. 311: G130-41, 2016.
PMID: 27173511
Support: Pilot and Feasibility
- "EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. Cheung
PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Jenny Lu HA, Brown D, Bouley R. J Am Soc
Nephrol. 27:3105-3116, 2016.
PMID: 27694161 PMCID: PMC5042667
Selected as an F1000 prime article
Support: Pilot and Feasibility
- Hostelley, T.L., Lodh, S., Zaghloul, N.A. (2016) “Whole organism transcriptome analysis of zebrafish
models of Bardet-Biedl Syndrome and Alstrom Syndrome provides mechanistic insight into shared and
divergent phenotypes.” BMC Genomics 17:318, 2016.
PMID: 27142762
Support: Pilot and Feasibility
- Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ, Köttgen M.
Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch. 469:303-311, 2017.
PMID: 27987038
Support: Core B
- Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic
Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell167:763-773, 2016.
PMID: 27768895,
Support: Core B
- Kleene SJ and Kleene NK. The native TRPP2-dependent channel of murine renal primary cilia. Am J
Physiol Renal Physiol. 312: F96-F108, 2017.
PMID: 27760766
Support: Pilot and Feasibility
- Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA,
Corey DP. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
PLoS One. 2016 May 19;11(5): e0155577. doi: 10.1371/journal.pone.0155577. eCollection 2016.
PMID: 27196058
Support: Core C
- Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J,
Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo
S. Isolated polycystic liver disease genes define effectors of polycystin-1 function. J Clin Invest 127: 1772-85, 2017. PMID: 28375157
Support: Core E
- Porath B, Gainullin VG, Cornec-Le Gall E, Dillinger EK, Heyer CM, Hopp K, Edwards ME, Madsen CD,
Mauritz SR, Banks CJ, Baheti S, Reddy B, Herrero JI, Bañales JM, Hogan MC, Tasic V, Watnick TJ, Chapman
AB, Vigneau C, Lavainne F, Audrézet MP, Ferec C, Le Meur Y, Torres VE; Genkyst Study Group, HALT
Progression of Polycystic Kidney Disease Group.; Consortium for Radiologic Imaging Studies of Polycystic
Kidney Disease., Harris PC. Am J Hum Genet. 98:1193-207, 2016.
PMID: 27259053
Support: Core E
- Wu Y, Xu JX, El-Jouni W, Lu T, Li S, Wang Q, Tran M, Yu W, Wu M, Barrera IE, Bonventre JV, Zhou J,
Denker BM, Kong T. Gα12 is required for renal cystogenesis induced by Pkd1 inactivation. J Cell Sci.
129:3675-3684, 2016.
PMID: 27505895 PMCID: PMC5087651
Support: Pilot and Feasibility
- Balbo BE, Amaral AG, Fonseca JM, de Castro I, Salemi VM, Souza LE, Dos Santos F, Irigoyen MC, Qian
F, Chammas R, Onuchic LF. Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3
knockout. Kidney Int. 90: 580-97, 2016.
PMID: 27475230
Support: Core B, C
- Dalagiorgou G, Piperi C, Adamopoulos C, Georgopoulou U, Gargalionis AN, Spyropoulou A, Zoi I,
Nokhbehsaim M, Damanaki A, Deschner J, Basdra EK, Papavassiliou AG. Mechanosensor polycystin-1
potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of
JAK2/STAT3 signaling axis. Cell Mol Life Sci. 74:921-936, 2017.
PMID: 27699453
Support: Core B
- Liu Y, Pejchinovski M, Wang X, Fu X, Castelletti D, Watnick TJ, Arcaro A, Siwy J, Mullen W9, Mischak H,
Serra AL. Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in
autosomal dominant polycystic kidney disease. Sci Rep. 2018 Apr 3; 8(1):5584. doi: 10.1038/s41598-018-22938. PMID: 29615724
Support: Core C
- Gulati A, Bae KT, Somlo S, Watnick T. Genomic Analysis to Avoid Misdiagnosis of Adults with Bilateral
Renal Cysts. Ann Intern Med. :130-131, 2018.
PMID: 29582070
Support: Core E
- Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu L-K, Lee P-H,
Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG. A
cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and
function when heterologously expressed. Sci Rep. 2018 Feb 9;8(1):2743. doi: 10.1038/s41598-018-20856-6.
PMID: 29426897 PMCID: PMC5807443
Support: Core C
- Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato
Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM,
Germino GG. NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic
model for ARPKD pathobiology. Sci Rep. 2017 Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4.
PMID: 28798345 PMCID: PMC5552802
Support: Core C
- Outeda P, Menezes L, Hartung EA, Bridges S, Zhou F, Zhu X, Xu H, Huang Q, Yao Q, Qian F, Germino
GG, Watnick T. A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin Cterminus in disease mechanism. Kidney Int 92:1130-1144, 2017.
PMID: 28729032
Support: Core B, C
- Seliger S, Abebe K, Hallows K, Miskulin D, Perrone R, Watnick T, Bae K. A Randomized Clinical Trial of
Metformin to treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 47:352-360, 2018.
PMID: 29779024
Support: Core E
- Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW,
Lambrechts D, Foijer F, Holland AJ. Centrosome Amplification Is Sufficient to Promote Spontaneous
Tumorigenesis in Mammals. Dev Cell 40:313-322, 2017.
PMID: 28132847 PMCID: PMC5296221
Support: Pilot and Feasibility
- Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Histone deacetylase 6 inhibition reduces cysts by
decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. J Biol Chem 292:17897-
17908, 2017.
PMID: 28887310 PMCID: PMC5663887
Support: Core C,D
- Rajani R1, Pastor-Soler NM, Hallows KR. Role of AMP-activated protein kinase in kidney tubular transport,
metabolism, and disease. Curr Opin Nephrol Hypertens 26: 375-383, 2017.
PMID: 28614117
Support: Pilot and Feasibility
- Yanda MK, Liu Q, Cebotaru L. An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and
cyst growth in polycystic kidney disease. Am J Physiol Renal Physiol 313: F997-F1004, 2017.
PMID: 28747357 PMCID: PMC5668593
Support: Core C
- Nie X, Arend LJ. Deletion of Pkd1 in renal stromal cells causes defects in the renal stromal compartment
and progressive cystogenesis in the kidney. Lab Invest. 97(12):1427-1438, 2017.
PMID: 28892094
Support: Core C
- He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL,
Bastepe M. Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron
levels in vivo. Proc Natl Acad Sci U S A. 114(45):E9559-E9568, 2017.
PMID: 29078380
Support: Pilot and Feasibility
- Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ, Köttgen M.
Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch 469:303-311, 2017. 1007/s00424-016-1924-4.
PMID: 27987038 PMCID: PMC5222933
Support: Core B
- Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A,
Wakimoto B, Schütze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T,
Köttgen M. The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.
PLoS Biol. 2018 Aug 6;16(8):e2005651. doi: 10.1371/journal.pbio.2005651.
PMID: 30080851
Support: Core B, D
- Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, Pan D. A RhoA-YAP-c-Myc signaling axis promotes the
development of polycystic kidney disease. Genes Dev. 32: 781-793, 2018.
PMID: 29891559
Support: Pilot and Feasibility, Core B, C
- Dixon EE, Woodward OM. Three-dimensional in vitro models answer the right questions in ADPKD
cystogenesis. Am J Physiol Renal Physiol. 315:F332-F335, 2018.
PMID: 29693448.
Support: Pilot and Feasibility, Core D
- Parnell SC, Magenheimer BS, Maser RL, Pavlov TS, Havens MA, Hastings ML, Jackson SF, Ward CJ,
Peterson KR Staruschenko A, Calvet JP. A mutation affecting polycystin-1 mediated heterotrimeric G-protein
signaling causes PKD. Hum Mol Genet. 27:3313-3324, 2018.
PMID: 29931260. PMCID: PMC6140781
Support: Core B
- Podrini C, Rowe I, Pagliarini R, Costa ASH, Di Meo I, Kim H, Chiaravalli M, Di Stefano G, Tiranti V, Qian F,
di Bernardo D, Frezza C, Boletta A. Dissection of Metabolic Reprogramming in Polycystic Kidney Disease
Reveals a Complex and Coordinated Rewiring of Bioenergetic Pathways. Commun Biol. 67:109495, 2018.
PMID: 30480096
Support Core B, C
- Welling PA. Autosomal dominant PKD gets an atomic map. Nat Rev Nephrol. 14:725-726, 2018.
PMID: 30279534
Support: Core D
- Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Role of calcium in adult onset polycystic kidney
disease. Cell Signal. 53:140-150, 2018.
PMID: 30296477
Support: Core B, D
- Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA,
Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC. Fully Automated
Echocardiogram Interpretation in Clinical Practice. Circulation. 138:1623-1635, 2018.
PMID: 30354459
Support: Core E
- Yanda MK, Liu Q, Cebotaru L. A potential strategy for reducing cysts in autosomal dominant polycystic
kidney disease with a CFTR corrector. J Biol Chem. 293:11513-11526, 2018.
PMID: 29875161
Support: Core C
- He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, Torline J, Huang Y, Zhao J, Ling K, Hu J. Axoneme
polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling. Nat
Commun. 9:3310, 2018.
PMID: 30120249 Free PMC Article
Support: Core B
- Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates CR, Li W, Dong B, Waters CM, Smith JC, Quarles LD.
Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest.
128:157-174, 2018.
PMID: 29202470 Free PMC Article
Support: Core C
- Kwak M, Hong C, Myeong J, Park EYJ, Jeon JH, So I. Gαi-mediated TRPC4 activation by polycystin-1
contributes to endothelial function via STAT1 activation. Sci Rep. 8:3480, 2018.
PMID: 29472562 PMCID: PMC5823873
Support: Core B
- Prasad H, Dang DK, Kondapalli KC, Natarajan N, Cebotaru V and Rao R. NHA2 promotes cyst
development in an in vitro model of polycystic kidney disease. J Physiol. 597:499-519, 2019.
PMID: 30242840
Support: Core B
- Fitzgibbon WR, Dang Y, Bunni MA, Baicu CF, Zile MR, Mullick AE, Saigusa T. Attenuation of accelerated
renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade. Am J Physiol Renal Physiol: 314:
F210-F218, 2018.
PMID: 29021226
Support: Core C
- Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T,
Yu ASL, Torres VE. A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan. J Am Soc
Nephrol. 29:2458-2470, 2018.
PMID: 30228150
Support: A, E
- Woodward O and Watnick T. Molecular Structure of the PKD Protein Complex Finally Solved. Am J Kidney
Dis. 73: 620-623, 2019.
PMID: 30704879
Support: Core D, A
- Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Role of calcium in adult onset polycystic kidney
disease. Cell Signaling 53:140-150, 2019.
PMID: 30296477
Support: Core C
- Kashyap P, Ng C, Wang Z, Li B, Arif Pavel M, Martin H, Yu Y. A PKD1L3 splice variant in taste buds is not
cleaved at the G protein-coupled receptor proteolytic site. Biochem Biophys Res Commun. 512:812-818, 2019.
PMID: 30928102
Support: Pilot and Feasibility
- Chu H, Shillingford JM, Reddy JA, Westrick E1, Nelson M, Wang EZ, Parker N, Felten AE, Vaughn JF, Xu
LC, Lu YJ, Vlahov IR, Leamon CP. Detecting Functional and Accessible Folate Receptor Expression in
Cancer and Polycystic Kidneys. Mol Pharm16: 3985-3995, 2019.
PMID: 31356752
Support: Core C
- Wang Z, Ng C, Liu X, Wang Y, Li B, Kashyap P, Chaudhry HA, Castro A, Kalontar EM, Ilyayev L, Walker
R, Alexander RT, Qian F, Chen XZ2, Yu Y. The ion channel function of polycystin-1 in the polycystin1/polycystin-2 complex. EMBO Rep. 2019 Aug 22: e48336. doi: 10.15252/embr.201948336. [Epub ahead of
print]
Support: Core B
- Hwang SH, Somatilaka BN, Badgandi H, Palicharla VR, Walker R, Shelton JM, Qian F, Mukhopadhyay S.
Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia. Curr Biol. 29:790-802, 2019.
PMID: 30799239
Support: Core B
- Lassen MCH, Qasim AN, Biering-Sørensen T, Reeh JLT, Watnick T, Seliger SL, Chen H, Sawan MA,
Nguyen D, Li Y, Hong SN, Park M. Cardiac function assessed by myocardial deformation in adult polycystic
kidney disease patients. BMC Nephrol. 20:324, 2019.
PMID: 31419965
Support: Core E, Pilot and Feasibility
- Palygin O, Ilatovskaya DV, Levchenko V, Klemens CA, Dissanayake L, Williams AM, Pavlov TS,
Staruschenko A. Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic
Signal: 14:485-497, 2018.
PMID: 30417216
Support: Pilot and Feasibility
- Arkhipov SN, Pavlov TS. ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC
activity. Biochem Biophys Res Commun. 513:166-171, 2019.
PMID: 30417216
Support: Pilot and Feasibility
- Ilatovskaya DV, Levchenko V, Pavlov TS, Isaeva E, Klemens CA, Johnson J, Liu P, Kriegel AJ,
Staruschenko A. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC).
EBioMedicine 40:663-674, 2019.
PMID: 30745171
Support: Pilot and Feasibility
- Paul P, Ramachandran S, Xia S, Unruh JR, Conkright-Fincham J, Li R. Dopamine receptor antagonists as
potential therapeutic agents for ADPKD. PLoS One. 2019 May 6;14(5):e0216220.
doi:10.1371/journal.pone.0216220, 2019.
PMID: 31059522
Support: Core A
- Román-Fernández Á, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE,
Bryant DM. The phospholipid PI(3,4)P2 is an apical identity determinant. Nat Commun. 2018 Nov
28;9(1):5041. doi: 10.1038/s41467-018-07464-8.
PMID: 30487552
Support: Pilot and Feasibility
- Hopp K, Cornec-Le Gall E, Senum SR, Te Paske IBAW, Raj S, Lavu S, Baheti S, Edwards ME, Madsen
CD, Heyer CM, Ong ACM, Bae KT, Fatica R, Steinman TI, Chapman AB, Gitomer B, Perrone RD, RahbariOskoui FF, Torres VE; HALT Progression of Polycystic Kidney Disease Group, the ADPKD Modifier Study,
Harris PC. Kidney Int. 97:370-382, 2020.
PMID: 31874800
Support: Core E, Pilot and Feasibility
- Chen H, Watnick T, Hong SN, Daly B, Li Y, Seliger SL. Left ventricular hypertrophy in a contemporary
cohort of autosomal dominant polycystic kidney disease patients. BMC Nephrol. 20:386, 2019.
PMID: 31653199
Support: Core E
- Wang K, Zelnick LR, Chen Y, Hoofnagle AN, Watnick T, Seliger S, Kestenbaum B. Alterations of Proximal
Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol15:80-88, 2020.
Support: Core E
- Nemenoff RA, Kleczko EK, Hopp K. Renal double negative T cells: unconventional cells in search of a
function. Ann Transl Med. 7(Suppl 8): S342, 2019.
PMID: 32016060 PMCID: PMC6976428
Support: Pilot and Feasibility
- Nowak KL, Hopp K. Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence
and Therapeutic Potential. In press Clin J Am Soc Nephrol. 2020
PMID: 32086281
Support: Pilot and Feasibility
- Nowak KL and Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cellular Signaling, 68:109518. doi: 10.1016/j.cellsig.2019.109518, 2020
PMID: 31881325 Support: Pilot and Feasibility
- Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM, Norris DP.
Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney
disease model. Nat Commun. 2019 Sep 6;10(1):4072. doi: 10.1038/s41467-019-12067-y.
PMID: 31492868
Support: Core B
- Holditch SJ , Brown CN, Atwood DJ, Pokhrel D, Brown SE, Lombardi AM, Nguyen KN, Hill RC, Lanaspa M,
Hopp K, Weiser-Evans MCM, Edelstein CL. The consequences of increased 4E-BP1 in polycystic kidney disease.
Hum Mol Genet. 28: 4132-4147, 2019.
Support: Core D, E
- Lea WA, McGreal K, Sharma M, Parnell SC, Zelenchuk L, Charlesworth MC, Madden BJ, Johnson KL, McCormick DJ, Hogan MC, Ward CJ. Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs). Sci Rep 10, 1500 (2020 doi: 10.1038/s41598-020-58087-3.
PMID: 32001768
Support: Core B
- Zimmerman KA, Huang J, He L, Revell DZ, Li Z, Hsu J-S, Fitzgibbon WR, Hazard ES, Hardiman G, Mrug M, Bell PD, Yoder BK, Saigusa T. Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney Disease. Kidney360 March 2020, 1 (3) 179-190; DOI: https://doi.org/10.34067/KID.0001052019 In Press, final not out yet
Support: Pilot and Feasibility
- Walker R, Xu H, Huang Q and Qian F. Biochemical Analysis of the Polycystin-1 Complexity Generated
by Proteolytic Cleavage at the G Protein-Coupled Receptor Proteolysis Site. In book: Polycystic Kidney Disease, pp.1-23. CRC Press eBook Published24 October 2019. DOI: 10.1201/9780429468834-1
Support: Core B
- Outeda P and Watnick T. Methods to Study the Vasculature in ADPKD. In book: Polycystic Kidney Disease. Boca Raton: CRC Press, 2019. eBook. DOI: 10.1201/9780429468834.
Support: Core C, A
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